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Home⇛International Journal of Multidisciplinary: Applied Business and Education Research⇛vol. 6 no. 8 (2025)

Nanocellulose and Phycocyanin as Viable Additives for Electrospun Fibers: A Review of Functional Properties, Electrospinning Parameters, and Physicochemical Characterization

Tabitha P. Vergel De Dios | Mia A. Luares | Myiesha Dane C. Calibara | Samuel Nelson G. Arboleda | John Ray C. Estrellado

Discipline: Development Studies

 

Abstract:

This literature review aims to highlight the developments and fu-ture directions in the use of nanocellulose and phycocyanin as elec-trospinning additives for biomedical applications, specifically in wound healing. Nanocellulose, a cellulose derivative known for its surface area, mechanical strength, and biocompatibility, is proposed as a sustainable alternative to enhancers of mechanical properties. Phycocyanin, a blue pigment from cyanobacteria, possesses anti-in-flammatory, antioxidant, and antimicrobial properties, which may potentially enhance the performance of nanocellulose. The combi-nation of the two components in electrospun fibers demonstrates significant promise for effective wound healing applications. How-ever, progress is limited by the scarcity of experimental studies in-tegrating both materials. One of the future directions of the study is improving the stability and shelf-life of phycocyanin within nano-fibers, including approaches such as encapsulation and protective coatings. Scaling and manufacturing challenges, including high en-ergy consumption and harsh chemical treatments in nanocellulose extraction, as well as the parameters of electrospinning, need to be addressed to enable mainstream commercialization. Further explo-ration of sustainable and purely physical extraction methods for nanocellulose is also critical for environmentally friendly alterna-tives to process scale-up and intensification.



References:

  1. Abazari,  M.  F.,  Gholizadeh,  S.,  Karizi,  S.  Z.,  Bir-gani,  N.  H.,  Abazari,  D.,  Paknia,  S.,  De-rakhshankhah,  H.,  Allahyari,  Z.,  Amini,  S. M.,  Hamidi,  M.,  &  Delattre,  C.  (2021).  Re-cent  Advances  in  Cellulose-Based  Struc-tures as the Wound-Healing Biomaterials: A  Clinically  Oriented  review. Applied  Sci-ences, 11(17), 7769.
  2. Adli, S. A., Ali, F., Azmi, A. S., Anuar, H., Nasir, N. a. M., Hasham, R., & Idris, M. K. H. (2020). Development  of  biodegradable  cosmetic patch  using  a  polylactic  Acid/Phycocya-nin–Alginate  composite. Polymers,  12(8), 1669.
  3. Ahmed,  S.,  Khan,  R.  A.,  &  Rashid,  T.  U.  (2025). Cellulose  nanocrystal  based  electrospun nanofiber  for  biomedical  applications–A review. Carbohydrate  Polymers,  348(Part A), 122838.
  4. Aruna, S. T., Balaji, L. S., Senthil Kumar, S., & Shri Prakash,   B.   (2017).   Electrospinning   in solid  oxide  fuel  cells –A  review. Renewa-ble  and  Sustainable  Energy  Reviews,  67, 673–682.
  5. Bakar, S. S. S., Fong, K. C., Eleyas, A., & Nazeri, M. F.  M.  (2018).  Effect  of  voltage  and  flow rate electrospinning parameters on polyacrylonitrile  electrospun  fibers. IOP Conference  Series  Materials  Science  and Engineering, 318, 012076.
  6. Bülbül, E.  Ö., Okur, M. E., Okur, N. Ü., & Siafaka, P.   I.   (2022).   Traditional   and   advanced wound  dressings:  physical  characteriza-tion  and  desirable  properties  for  wound healing.  In Elsevier  eBooks(pp.  19–50).
  7. Chen,  K.,  Hu,  H.,  Zeng,  Y.,  Pan,  H.,  Wang,  S., Zhang, Y., Shi, L., Tan, G., Pan, W., & Liu, H. (2022).  Recent  advances  in  electrospun nanofibers for wound dressing. European Polymer Journal, 178, 111490.
  8. Couret,  L.,  Irle,  M.,  Belloncle,  C.,  &  Cathala,  B. (2017). Extraction and characterization of cellulose    nanocrystals    from    post-con-sumer  wood  fiberboard  waste. Cellulose, 24(5), 2125–2137.
  9. Das,  S.  K.,  Chakraborty,  S.,  Naskar,  S.,  &  Ra-jabalaya, R. (2021). Techniques and meth-ods  used  for  the  fabrication  of  bionano-composites.  In Elsevier  eBooks(pp.  17–43).
  10. De Vrieze, S., Van Camp,  T., Nelvig, A. et al. The effect  of  temperature  and  humidity  on electrospinning. J   Mater   Sci   44,   1357–1362 (2009).
  11. Dranseikien臈,  D.,  Bal膷i奴nait臈-Murzien臈,  G., Karosien臈,   J.,   Morudov,   D., Juod啪iukynien臈,  N.,  Hudz,  N.,  Ger鈥慴utavi膷ien臈, R. J., & Savickien臈, N. (2022). Cyano-Phycocyanin:   Mechanisms   of   ac-tion  on  human  skin  and  future  perspec-tives   in   medicine. Plants,   11(9),   1249.
  12. Dumanli,  A.  G.  (2016).  Nanocellulose  and  its Composites  for  Biomedical  Applications. Current  Medicinal  Chemistry, 24(5),  512–528.de Dioset al., 2025 /Nanocellulose and Phycocyanin as Viable Additives for ElectrospunFibersIJMABER 3837Volume 6| Number 8| August | 2025https://doi.org/10.2174/0929867323666161014124008
  13. Fernandes,  R.,  Campos,  J.,  Serra,  M.,  Fidalgo,  J., Almeida, H., Casas, A., Toubarro, D., & Bar-ros, A. I. R. N. A. (2023). Exploring the ben-efits of  phycocyanin: from  spirulina culti-vation   to   its   widespread   applications. Pharmaceuticals, 16(4), 592.
  14. Fu, Y., and Zhu, J. (2021). "Green design and re-cycling systems for solving the dilemma of disposable  chopsticks  waste  caused  by online  food  delivery:  A  review," BioRe-sources 16(4), 8640-8656.https://doi.org/10.15376/bio-res.16.4.fu
  15. Gao,  M.,  Yang,  Z.,  Liang,  W.,  Ao,  T.,  &  Chen,  W. (2023).   Recent   advanced   freestanding pseudocapacitive  electrodes  for  efficient capacitive   deionization.   Separation   and Purification    Technology,    324,    124577.
  16. Ghomi,   E.   R.,   Khalili,   S.,   Khorasani,   S.   N., Neisiany,  R.  E.,  &  Ramakrishna,  S.  (2019). Wound  dressings:  Current  advances  and future  directions. Journal  of  Applied  Poly-mer Science, 136(27).
  17. Goswami, R., Singh, S., Narasimhappa, P., Rama-murthy,  P.  C.,  Mishra,  A.,  Mishra,  P.  K., Joshi,  H.  C.,  Pant,  G.,  Singh,  J.,  Kumar,  G., Khan, N. A., & Yousefi, M. (2024). Nanocel-lulose:  A  comprehensive  review  investi-gating its potential as an innovative mate-rial  for  water  remediation. International Journal    of    Biological    Macromolecules, 254(Part 3), 127465.
  18. Hao,  Q.,  Schossig,  J.,  Davide,  T.,  Towolawi,  A., Zhang,  C.,  &  Lu,  P.  (2024).  Gravity-Driven Ultrahigh-Speed  Electrospinning  for  the Production  of  Ethyl  Cellulose  Fibers  with Tunable  Porosity  for  Oil  Absorption. ACS Sustainable    Chemistry    &    Engineering, 13(1), 507–517.
  19. Hsieh, Y. (2018). Cellulose Nanofibers: Electro-spinning and Nanocellulose Self鈥慉ssem鈥慴lies. Advanced  Green  Composites,  67–95.
  20. Izadi, M., & Latifi, E. (2022). Comparison of the antibacterial  properties  of  phycocyanin and its SNPs and their effects on rat blood cells  and  liver  enzymes. Beni-Suef  Univer-sity  Journal  of  Basic  and  Applied  Sciences, 11(1).
  21. Ji, X., Guo, J., Guan, F., Liu, Y., Yang, Q., Zhang, X., &  Xu,  Y.  (2021).  Preparation  of  electro-spun     polyvinyl     Alcohol/Nanocellulose composite  film  and  evaluation  of  its  bio-medical   performance. Gels, 7(4),   223.
  22. Jodnok, S., Choeisai, P., Kruehong, C., & Choeisai, K.  (2021b).  Recycling  disposable  bamboo chopstick waste as a renewable energy re-source:  Case  study  in  Khon  Kaen  Univer-sity,   Thailand. Sustainable   Environment Research, 31(1).
  23. Kargarzadeh,  H.,  Huang,  J.,  Lin,  N.,  Ahmad,  I., Mariano,  M.,  Dufresne,  A.,  Thomas,  S.,  & Ga艂臋ski, A. (2018). Recent developments in     nanocellulose-based     biodegradable polymers,   thermoplastic   polymers,   and porous nanocomposites. Progress in Poly-mer Science, 87,197–227.
  24. Kaya, S., & Derman, S. (2023). 陌DEAL YARA ÖRTÜSÜNÜN ÖZELL陌KLER陌. Ankara  Uni-versitesi  Eczacilik  Fakultesi  Dergisi, 47(3), 5. https://doi.org/10.33483/jfpau.1253376Khandual, S., Sanchez, E. O. L., Andrews, H. E., & De  La  Rosa,  J.  D.  P.  (2021).  Phycocyanin content  and  nutritional  profile  of  Arthro-spira  platensis  from  Mexico:  efficient  ex-traction  process  and  stability  evaluation of   phycocyanin. BMC   Chemistry,   15(1). https://doi.org/10.1186/s13065-021-00746-1de Dioset al., 2025 /Nanocellulose and Phycocyanin as Viable Additives for ElectrospunFibersIJMABER3838Volume 6| Number 8| August| 2025
  25. Khodayari,  A.,  Vats,  S.,  Mertz,  G.,  Schnell,  C.  N., Fuentes  Rojas,  C.,  &  Seveno,  D.  (2025). Electrospinning of cellulose nanocrystals: Procedure    and    optimization. Carbohy-drate Polymers, 347, 122698.
  26. Kumar,  P.,  Miller,  K.,  Kermanshahi-Pour,  A., Brar, S. K., Beims,  R. F.,  & Xu, C. C. (2022). Nanocrystalline   cellulose   derived   from spruce wood: Influence of process param-eters. International  Journal  of  Biological Macromolecules, 221, 426–434.
  27. Leong, M., Kong, Y., Harun, M., Looi, C., & Wong, W. (2023). Current advances of nanocellu-lose application in biomedical field. Carbo-hydrate Research, 532, 108899.
  28. Luo, C. (2013). China’s 80 billion disposable chopsticks   a   burden   on   forests.   Hong Kong: South China Morning Post.
  29. Meng, Z., Liu, J., Zhang, R., Ren, Y., Qi, Q., Cui, B., Gou, Y., Zhuang, S., Zhao, T., Liu, Q., Bao, X., & Ren, C. (2025). Phycocyanin-based mul-tifunctional   hydrogel   with   self-healing, hemostatic,  antioxidative,  and  antibacte-rial  activity  for  wound  healing. Interna-tional   Journal   of  Biological   Macromole-cules, 310(Part 2), 143254.
  30. Moon,  R.J.,  Schueneman,  G.T.  &  Simonsen,  J. Overview    of    Cellulose    Nanomaterials, Their  Capabilities  and  Applications. JOM 68, 2383–2394 (2016).
  31. Mouro,  C.,  &  Gouveia,  I.  C.  (2023).  Electrospun wound  dressings  with  antibacterial  func-tion: a critical review of plant extract and essential   oil   incorporation. Critical   Re-views  in  Biotechnology,  44(4),  641–659.
  32. Muraleedharan,  M.  N.,  Karnaouri,  A.,  Piatkova, M.,  Ruiz-Caldas,  M.,  Matsakas,  L.,  Liu,  B., Rova, U., Christakopoulos, P., & Mathew, A. P.  (2021).  Isolation  and  modification  of nano-scale    cellulose    from    organosolv-treated  birch  through  the  synergistic  ac-tivity of LPMO and endoglucanases. Inter-national  Journal  of  Biological  Macromole-cules, 183, 101–109.
  33. Mutlu, B., Çaylak, S., & Duman, 艦. (2022). Incor-poration  of  cerium  oxide  into  hydroxyap-atite/chitosan composite scaffolds for bone repair.
  34. Mutlu, G.,  Calamak,  S., Ulubayram, K., & Guven, E.  (2017).  Curcumin-loaded  electrospun PHBV   nanofibers   as   potential   wound-dressing material. Journal of Drug Delivery Science   and   Technology, 43,   185–193.
  35. Patil, T. V., Patel, D. K., Dutta, S. D., Ganguly, K., Santra,  T.  S.,  &  Lim,  K. (2021).  Nanocellu-lose, a versatile platform: From the deliv-ery of active molecules to tissue engineer-ing   applications. Bioactive   Materials,   9, 566–589.
  36. Pellegrino,  P.,  Bramanti,  A.  P.,  Farella,  I.,  Cas-cione,  M.,  De  Matteis,  V.,  Della  Torre,  A., Quaranta,  F.,  &  Rinaldi,  R.  (2022).  Pulse-Atomic   Force   Lithography:   a   powerful nanofabrication   technique   to   fabricate constant  and  Varying-Depth  nanostruc-tures. Nanomaterials, 12(6), 991.
  37. Raju, V., Revathiswaran, R., Subramanian, K. S., Parthiban, K. T., Chandrakumar, K., Anoop, E. V., & Chirayil, C. J. (2023). Isolation and characterization of nanocellulose from se-lected  hardwoods,  viz.,  Eucalyptus  tereti-cornis  Sm.  and  Casuarina  equisetifolia  L., by  steam  explosion  method. Scientific  Re-ports, 13(1).
  38. Refate,  A.,  Mohamed,  Y.,  Mohamed,  M.,  Sobhy, M., Samhy, K., Khaled, O., Eidaroos, K., Ba-de Dioset al., 2025 /Nanocellulose and Phycocyanin as Viable Additives for ElectrospunFibersIJMABER 3839Volume 6| Number 8| August | 2025
  39. tikh,  H.,  El-Kashif,  E.,  El-Khatib,  S.,  &  Me-hanny, S. (2023). Influence of electrospin-ning  parameters  on  biopolymers  nano-fibers,  with  emphasis  on  cellulose  &  chi-tosan. Heliyon, 9(6), e17051.
  40. Resch,  A.,  Staud,  C.,  &  Radtke,  C.  (2021).  Nano-cellulose鈥慴ased wound dressing for con鈥憇ervative wound management in children with second鈥慸egree burns. International Wound Journal, 18(4), 478–486.
  41. Ribeiro,   A.   S.,   Costa,   S.   M.,   Ferreira,   D.   P., Calhelha, R. C., Barros, L., Stojkovi膰, D., Sokovi膰, M., Ferreira, I. C., & Fangueiro, R. (2021).   Chitosan/nanocellulose   electro-spun  fibers  with  enhanced  antibacterial and antifungal activity for wound dressing applications. Reactive  and  Functional  Pol-ymers/Reactive   &   Functional   Polymers, 159, 104808.
  42. Safari, R., Amiri, Z. R., & Kenari, R. E. (2020). An-tioxidant and antibacterial activities of  C-phycocyanin  from  common  name  Spir-ulina platensis. Iranian Journal of Fisheries and Sciences, 19(4), 1911–1927.
  43. Shankaran, D. R. (2018). Cellulose nanocrystals for  health  care  applications.  In Elsevier eBooks (pp. 415–459).
  44. Shanmugam,  A.,  Sigamani,  S.,  Venkatachalam, H.,    Jayaraman,    J.,    &    Ramamurthy,    D. (2017). Antibacterial activity of extracted phycocyanin  from  Oscillatoria  sp. Journal of Applied Pharmaceutical Science.
  45. Sihag,  S.  S.,  Pal,  J.,  &  Yadav,  M.  (2022).  Extrac-tion  and  Characterization  of  Nanocellu-lose  from  Wheat  Straw:  Facile  Approach. Journal of Water and Environmental Nano-technology, 7(3), 317-331.
  46. Singh, H., Verma, A. K., Trivedi, A. K., & Gupta, M. (2023). Characterization of nanocellulose isolated  from  bamboo  fibers. Materials Today: Proceedings.
  47. Singh, Y. P., Dasgupta, S., Nayar, S., & Bhaskar, R. (2020).  Optimization  of  electrospinning process  &  parameters  for  producing  de-fect-free     chitosan/polyethylene     oxide nanofibers  for  bone  tissue  engineering. Journal  of  Biomaterials  Science, Polymer Edition, 31(6), 781–803.
  48. Suzuki,  A.,  Sasaki, C.,  Asada, C.,  & Nakamura, Y. (2018). Production of cellulose nanofibers from  Aspen  and  Bode  chopsticks  using  a high    temperature    and    high    pressure steam  treatment  combined  with  milling. Carbohydrate   Polymers, 194,   303–310.
  49. Tamo,  A.  K.  (2024).  Nanocellulose-Based  Hy-drogels  as  Versatile  Bio-Based  Materials with Interesting Functional Properties for Tissue  Engineering  Applications. Journal of  Materials  Chemistry  B, 12(32),  7692–7759.
  50. The Economist. (2014, September 13). Sticks in the gullet. The Economist.
  51. Tripatanasuwan, S., Zhong, Z., & Reneker, D.  H. (2007). Effect of evaporation  and solidifi-cation  of  the  charged  jet  in  electrospin-ning  of  poly(ethylene  oxide)  aqueous  so-lution. Polymer,     48(19),     5742–5746.
  52. Trushina,  D.  B.,  Borodina,  T.  N.,  Belyakov,  S.,  & Antipina, M. N. (2022). Calcium carbonate vaterite  particles  for  drug  delivery:  Ad-vances  and  challenges. Materials  Today Advances, 14, 100214. https://doi.org/10.1016/j.mtadv.2022.100214de Dioset al., 2025 /Nanocellulose and Phycocyanin as Viable Additives for ElectrospunFibersIJMABER3840Volume 6| Number 8| August| 2025
  53. Usov, I., Nyström, G., Adamcik, J., Handschin, S., Schütz,  C.,  Fall,  A.,  Bergström,  L.,  &  Mez-zenga, R. (2015). Understanding  nanocel-lulose  chirality  and  structure–properties relationship  at  the  single  fibril  level. Na-ture Communications, 6(1).
  54. Vergel De Dios, T. P., Luares, M. A., Arboleda, W., Calibara,  M.  D.  C.,  &  Estrellado,  J.  R.  C. (2025).  Multi-Objective  Taguchi  Optimi-zation  of  Electrospinning  Parameters  for the    Development    of    Poly-(vinyl    alco-hol)/Waste   Wooden   Utensil   Nanocellu-lose/Phycocyanin  Electrospun  Fibers. In-ternational   Journal   of   Multidisciplinary: Applied  Business  and  Education  Research, 6(6), 3045-3069.
  55. Wang,  D.,  Cheng,  W.,  Yue,  Y.,  Xuan,  L.,  Ni,  X.,  & Han,   G.   (2018).   Electrospun   Cellulose Nanocrystals/Chitosan/Polyvinyl  Alcohol Nanofibrous  Films  and  their  Exploration to    Metal    Ions    Adsorption. Polymers, 10(10), 1046.
  56. Wcw-Admin-Support. (2023, April 28). Types of wound  dressings  and  when  to  use  them. West     Coast     Wound     &     Skin Care.
  57. Yang, G.-Z., Li, H.-P., Yang, J.-H., Wan, J., & Yu, D.-G.  (2017).  Influence  of  working  tempera-ture on the formation of electrospun poly-mer  nanofibers. Nanoscale  Research  Let-ters, 12(1), 55.
  58. Zahra,  F.  T.,  Zhang,  Y.,  Ajayi,  A.  O.,  Quick,  Q.,  & Mu,  R.  (2024).  Optimization  of  electro-spinning  parameters  for  lower  molecular weight  polymers:  A  case  study  on  polyvi-nylpyrrolidone. Polymers,   16(9),   1217.
  59. Zaman, H. U., Islam, J., Khan, M. A., & Khan, R. A. (2011).  Physico-mechanical  properties  of wound dressing material and its biomedi-cal  application. Journal  of  the  Mechanical Behavior  of  Biomedical  Materials/Journal of  Mechanical  Behavior  of  Biomedical  Ma-terials, 4(7), 1369–1375.
  60. Zhao, J., Zhang, W., Zhang, X., Zhang, X., Lu, C., & Deng,  Y.  (2013).  Extraction  of  cellulose nanofibrils  from  dry  softwood  pulp  using high shear homogenization. Carbohydrate Polymers, 97(2), 695–702.
  61. Zhou, R., Ma, Y., Yang, M., Cheng, Y., Ma, X., Li, B., Zhang,  Y.,  Cui,  X.,  Liu,  M.,  Long,  Y.,  &  Li,  C. (2025).  Wound  dressings  using  electro-spun   nanofibers:   mechanisms,   applica-tions, and future directions. European Pol-ymer Journal,113900.  

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